Intracellular Trafficking of Proteins

Academy of Sciences activity addition amino acids antibodies apical appears assembly associated binding Biochemical Biochemistry Biological Chemistry Cell Biology cell surface cellular characterization clathrin coated pits coated vesicles compartment complex components contain cytoplasmic cytosol degradation demonstrated direct domain effect endocytic endocytosis endosomes enzymes et al evidence expression fraction function fusion gene glycoproteins glycosylation Golgi Golgi complex growth factor hepatocytes human identified import indicate inhibited interaction internalized intracellular involved isolated Journal of Biological Journal of Cell ligand localization lysosomal mechanism membrane proteins mitochondrial molecular molecules mutant National Academy Nature normal nuclear observed occurs organelles pathway peroxisomal plasma membrane polypeptide precursor present Proceedings proteins rat liver recently receptor recycling region regulation residues Review ricin role secretion secretory sequence shown signal similar sorting specific structure studies suggest synthesized toxin transferrin receptor translocation transport types