The FOS and JUN Families of Transcription FactorsCRC Press, 29/09/1994 - 322 من الصفحات This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins. |
المحتوى
General Structure of AP1 Subunits and Characteristics of | 7 |
Chapter | 10 |
Gene and Protein Structure Homologies | 15 |
Adenovirus E1AAP1 Connection | 18 |
A ProteinProtein Interactions | 21 |
Factors Modulating AP1 Activity | 41 |
Chapter 4 | 49 |
B Posttranslational Modification | 61 |
Identification of AP1Regulated Genes | 133 |
B Neural Cell Function | 151 |
Chapter 12 | 163 |
Stress Response | 169 |
Functions in Pathology | 191 |
Chapter 15 | 203 |
B Oncogenes Acting Through Fos and | 221 |
Chapter 17 | 249 |
Chapter 6 | 71 |
Nuclear Uptake | 87 |
Promoter Regulation | 97 |
Chapter 9 | 115 |
Containing Jun Fos and ATFCREB Members | 261 |
Tumor Promotion and Carcinogenesis | 275 |
E Tumor Progression | 295 |
طبعات أخرى - عرض جميع المقتطفات
عبارات ومصطلحات مألوفة
Acad amino acids Angel AP-1 activity Biol c-fos c-fos expression c-fos gene c-fos promoter c-Jun c-jun promoter C-terminal cell lines cellular Chem cJun collagenase CREB Curran cytoplasm differentiation dimerization DNA binding domain EMBO enhancer fibroblasts Fos and Jun fos gene Fos proteins Fos/Jun fosB function gene expression Genes Dev growth factor Herrlich heterodimers hormone human induced inhibition interaction Jun proteins JunB Karin leucine zipper Lucibello MAP kinase mediated mitogenic mouse mRNA Müller mutations Natl negative regulation neurons nuclear okadaic acid Oncogene overexpression phorbol esters phosphatases phosphorylation posttranslational modification potential Proc protein kinase proto-oncogene Rahmsdorf Rapp region regulatory repression Sassone-Corsi Schönthal sequences serines serum response element signal transduction signal transduction pathways Smeal specific stimulation synthesis target ternary complex Tjian transactivation transactivation domain transcription factors transcriptional activation transfection transformation transrepression Treisman tumor v-Jun Verma vitro vivo Vogt Ziff