Protein targeting, transport & translocation
This book presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Key Features * Basic principles and techniques * Targeting and sorting sequences * Protein export in bacteria * Membrane protein integration into ER and bacterial membranes * Protein translocation across the ER * Disulfide bond formation in prokaryotes and eukaryotes * Quality control in the export pathway * Import of proteins into organelles * The secretory pathway * Vesicular transport * Spectacular color throughout
Internet Resources
1 online resource (xiv, 424 pages) : illustrations (some color)
9780122007316, 9780080480503, 012200731X, 0080480500
162571619
Introduction
Overview
Methods in Protein Targeting, Translocation and Transport
Targeting Sequences
Protein Export in Bacteria
Protein Sorting at the Membrane of the Endoplasmic Reticulum
Membrane Protein Insertion into Bacteial Membranes and Endoplasmic Reticulum
Disulfide Bond Formation in Prokaryotes and Eukaryotes
The Unfolded Protein Response
Protein Quality Control in the Export Pathway: The Endoplasmic Reticulum and its Cytoplasmic Proteasome Connection
Translocation of Proteins into Mitochondria
The Import and Sorting of Protein into Chloroplasts
Import of Proteins into Peroxisomes
Nucleocytoplasmic Transport
Protein Transport to the Yeast Vacuole
The Secretory Pathway
Vesicular Transport
Conclusion/Perspective. Introduction/overview
Ross E. Dalbey, Gunnar von Heijne
Methods in protein targeting, translocation and transport / Ross E. Dalbey, Minyong Chen, Martin Wiedmann
Targeting sequences / Gunnar von Heijne
Protein export in bacteria / Arnold J.M. Driessen, Chris van der Does
Protein sorting at the membrane of the endoplasmic reticulum / Nora G. Haigh, Arthur E. Johnson
Membrane protein insertion into bacterial membranes and the endoplasmic reticulum / Andreas Kuhn, Martin Spiess
Disulfide bond formation in prokaryotes and eukaryotes / James Regeimbal, James C.A. Bardwell
The unfolded protein response / Carmela Sidrauski, Jason H. Brickner, Peter Walter
Protein quality control in the export pathway: the endoplasmic reticulum and its cytoplasmic proteasome connection / Zlatka Kostova, Dieter H. Wolf
Translocation of proteins into mitochondria / Thorsten Prinz, Nikolaus Pfanner, Kaye N. Truscott
The import and sorting of protein in chloroplasts / Jürgen Soll, Colin Robinson, Lisa Heins
Import of proteins into peroxisomes / Suresh Subramani [and others]
Nucleocytoplasmic transport / Dirk Görlich, Stefan Jäkel
Protein transport to the yeast vacuole / Todd R. Graham, Steven F. Nothwehr
The secretory pathway / Benjamin S. Glick
Vesicular transport / Joachim Ostermann, Tobias Stauber, Tommy Nilsson
Conclusion/perspective / Ross E. Dalbey, Gunnar von Heijne
Referex An electronic book accessible through the World Wide Web; click for information